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Pathophysiology of multiple sclerosis lesions

Emmanuelle L. Waubant, Jorge R. Oksenberg, Donald E. Goodkin
From: Science & Medicine: Volume 4 Number 6: Page 32 (December 1997)

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Abstract: The etiology of multiple sclerosis remains unknown, but there have been important advances in defining the cascade of immunological events that accompany the formation of new MS plaques. As a result, potential mechanisms of action of recently approved and emerging forms of treatment for relapsing MS can be better explained. The current paradigm for the immunopathogenesis of MS is based upon complicated interactions of cells, cytokines, and chemokines that are still incompletely understood. Consequently, current hypotheses may prove to be incorrect, but with each scientific advance will come a new therapy that can be empitically tested in clinical trials.

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