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Bioenineered skin substitutes

Jeffrey R. Morgan, Martin L. Yarmush
From: Science & Medicine: Volume 4 Number 4: Page 6 (August 1997)

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Abstract: Wound coverage for patients with extensive burns has traditionally been provided by temporary grafts of cadaver skin. Efforts to develop effective skin substitutes bore their first fruit about 20 years ago, and cultures of patients' own epidermal keratinocytes have been available to surgeons for quite some time. Recently introduced products inclued acellular dermal analogs, which promote ingrowth and vascularization from the wound bed, and temporary skin substitutes that encourage wound healing. Applications already go beyond burns, and gene thatapy techniques may furter ixtend the use of skin substitutes.

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