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The molecular basis of insulin resistance

Jack F. Youngren, Ira D. Goldfine
From: Science & Medicine: Volume 4 Number 3: Page 18 (June 1997)

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Abstract: Insulin resistance is important in the pathogenesis of non-insulin dependent diabetes mellitus. Even in the absence of diabetes, hyperinsulinemia contributes to the clustering of cardiovascular risk factors termed Syndrome X. Insulin resistance is a complex phenotype, with both genetic and lifestyle factors contributing to it, so that the exact cellular mechanisms have not been firmly established. Defects in insulin receptor signaling capacity are the most likely cause of diminished insulin action. Mutations of insulin receptor genes account for only a small percentage of cases of insulin resistance in humans. Therefore the impact of intracellular effectors of the insulin repceptor such as membrane glycoprotein PC-1 is being examined.

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