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Environmental influences on breast cancer risk

Devra Lee Davis, Deborah Axelrod, Michael P. Osborne, Nitin T. Telang
From: Science & Medicine: Volume 4 Number 3: Page 56 (June 1997)

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Abstract: Fewer than 10% of breast cancers develo because of inherited genetic defects, and known risk factors do not explain most sporadic cases. Excepting radiation, most estavlished breast cancer risk factors are linked with total lifetime exposure to estrogen. Experimental work and wildlife studies reveal that environmental chemicals can disrupt hormone production and metabolism, directly or indirectly. Exposure to xenogormonal substances and tobacco smoke could account for some cases of breast cancer. biologic markers are under development to permit identification of persons at risk and assessment of potential interventions.

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