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Adenoviruses as vectors for gene therapy

Joanne T. Douglas, David T. Curiel
From: Science & Medicine: Volume 4 Number 2: Page 44 (April 1997)

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Abstract: Recombinant adenoviruses are attractive gene delivery vehicles because they are stable in the bloodstream and deliver genes efficiently. Trials of adenovirus-mediated gene therapy in animal models, however, disclosed vector immunogenicity and lack of cell-specific targeting as problems that thriatened to resrict the use of adenoviral vectors. While the current generation of adenoviral vectors is already being widely used in Phase I human trials, rational strategies have been proposed to surmount the hurdles. Experimental results suggest that the next generation of vectors will allow gene therapy to be attempted for a range of diseases not now amenable to adenovirus-mediated gene delivery.

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