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Blood substitutes

Robert M. Winslow
From: Science & Medicine: Volume 4 Number 2: Page 54 (April 1997)

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Abstract: Development of blood substitutes was triggered in the 1980's by HIV contamination of the blood supply and by the U.S. Army's interest in a new battlefield resuscitation solution that would avoid the logistical problems of whole blood. Though the aims have changed, cell-free oxygen carriers continue in active development for several potential clinical indications. No products have been put on the market, in part because establishing their safety and efficacy compared to transfusion will not be easy. Of equal importance, these blood substitutes appear to have unanticipated effects on the auto-regulation of blood flow.

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