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Preventing HIV-1 drug resistance

Jon H. Condra, Emilio A. Emini
From: Science & Medicine: Volume 4 Number 1: Page 14 (February 1997)

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Abstract: viruses with RNA genomes are especially likely to mutate because their replication enzymes do not incorporate proof-reading functions. Drug-resistant HIV-1 variants may be present even before treatment and typically arise rapidly in treated patients, limiting the effectiveness of most anti-HIV-1 therapies. Knowledge of the genetics of viral resistance and the availability of potent new therapeutic regimens makes it possible to substantially forestall HIV-1 drug resistance. The result is prolonged drug-mediated virus supression.

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