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Intracellular antibodies for HIV-1 gene therapy

Lingxun Duan, Roger J. Pomerantz
From: Science & Medicine: Volume 3 Number 3: Page 24 (June 1996)

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Abstract: Two approaches to gene therapy of HIV infection have been proposed: genetic modification of differentiated peripheral blood mononuclear cells ex vivo, and gene transfer into hematopoietic stem or progenitor cells ex vivo. An important element in either strategy is the development of specific target-blocking moieties that inhibit viral replication. Synthesized single-chain antibodies targeted to particular intracellular compartments can inhibit replication at various stages of the viral life cylce. As a simple and effective new method, intracellular antivodies are likely to have widespread impact on biological research and as potential therapeutic agents.

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