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Insulin-like growth factors

William L. Lowe, Jr.
From: Science & Medicine: Volume 3 Number 2: Page 62 (April 1996)

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Abstract: Structurally resembling insulin and with some similar actions, the two insulin-like growth factors are transported in plasma and delivered to cell membrane receptors by six different binding proteins. IGF-I increases glucose and amino acid uptake and stimulates sythesis of protein and RNA, and in some cell types it promotes DNA synthesis and cell differentiation and prevents apoptosis. IGF-II, though abundant, has no known physiologic role in adults. The IGF binding proteins also have specific actions independent of the growth factors themselves.

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