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Estrogen receptors in breast cancer therapy

C. Kent Osborne, Richard M. Elledge, Suzanne A.W. Fuqua
From: Science & Medicine: Volume 3 Number 1: Page 32 (February 1996)

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Abstract: Tamoxifen works by competitively binding to intracellular estrogen receptors. Limiting the opportunities for estrogen to exert its proliferative effects controls the growth of breast cancer by holding the tumor cells in the G1 phase of the cell cycle. But tamoxifen also has estrogenic effects, in part because the estrogen receptor has more than one site through which it induces transcriptional activity. Steroidal anti-estrogens now in clinical trials and possible new agents based on the best current understanding of estrogen receptor function hold promise for improved control of breast cancer.

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