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Genomic imprinting

Andrew R. Hoffman, Thanh H. Vu
From: Science & Medicine: Volume 3 Number 1: Page 52 (February 1996)

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Abstract: An unknown biochemical event that occurs while maternal and paternal genomes are separated apparently causes the two alleles of certain genes to be differentially rather than equally expressed in offspring. The phenomenon is known as genomic imprinting, and it may be the basis, for example, of the increased risk of developing Type I diabetes when the predisposition has been inherited from the paternal chromosome. Known imprinted genes occur close together on the human genome, but imprinting may not be a large-scale event.

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