Science & Medicine
Home | Current Issue | Archives | Subscriptions | Contact Us

Log In | Search | Author Index | Advertising

Signal transduction pathways as drug targets

Alan R. Saltiel
From: Science & Medicine: Volume 2 Number 6: Page 58 (December 1995)

View Full TextAdd To BasketPurchase Images

Abstract: When growth factors bind to plasma membrane-bound receptors, they initiate a cascade of protein phosphorylations that collectively make up a path of signal transmission and reception leading to nuclear transcription factors. Enzymes phosphorylating proteins on tyrosine kinases, and proteins that bind to phosphotyrosine, form the linnks in the signal transduction chain. Structural alterations in the enzymes or transducing proteins arise when their genes are mutated and induce dysregulation of cell growth. Such mutations are associated with some human cancers. therefore, signal transduction is a target for development of new antiproliferative drugs.

Back to Table of Contents



Science & Medicine, Inc.
P.O. Box 313, Narberth, PA 19072
(610) 660-8097       (800) 888-0028
fax (610) 660-0348
e-mail editor@sciandmed.com
See our other journal: Medical Problems of Performing Artists.
Home | Current Issue | Archives | Subscriptions | Contact Us

Log In | Search | Author Index | Advertising

Copyright © 2002-2019, Science & Medicine, Inc.

Powered by Pliner Solutions, Inc.
Web Development by Pliner Solutions, Inc.