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Genetic effects of DNA packaging

Alan P. Wolffe
From: Science & Medicine: Volume 2 Number 6: Page 68 (December 1995)

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Abstract: The genetic blueprint is stored, transcribed, and ingerited within the chromosomes. Each chromosome has long been recognized as having a precise architecture assembled by the progressive coiling of the single DNA molecule into increasingly compact structures. Recent experiments have established that the regulation of this coiling within the chromosome has a significant impact on the properties of the genes themselves. Thalassemia, several neuromuscular diseases, and even male sex determination dcan all potentially be explained by the altered assembly of chromosomal structures.

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