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Hormonal manipulation to prevent breast cancer

Darcy V. Spicer, Malcolm C. Pike
From: Science & Medicine: Volume 2 Number 4: Page 58 (August 1995)

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Abstract: Repetitive cell proliferation is important in the genesis of many human neoplasms. It increases the probability of somatic-cell genetic errors and hence the likelihood of malignancy. Most breast cancers arise from epithelial cells of the terminal duct lobular unit. Proliferation of these epithelial cells is predominantly controlled by the ovarioan sex-steroid hormones estrogen and progesterone. Premenopausal exposure to these steroid hormones accounts for the steep rise in breast cancer risk seen in premenopausal women. Reducing exposure to these hormones is expected to reduce breast cancer incidence.

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