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A Bright Future for the Sunshine Hormone

Daniel D. Bikle
From: Science & Medicine: Volume 2 Number 2: Page 58 (April 1995)

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Abstract: Regulation of calcium and phosphate handling through both receptor-mediated and local effects on intestine, bone, and kidney is the best studied and undoubtedly the most important physiologic action of 1,25-(OH)2D, the hormonally active metabolite of vitamin D. However, the existence of the vitamin D receptor in many other cell types and in tumors of those tissues offers prospects for therapeutic uses of 1,25-(OH)2D, except that the high doses required induce hypercalcemia. Analogs now being developed and tested are not hypercalcemic at effective doses. Elucidation of these new actions of vitamin D promises wider applications of such products.

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