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Tumor suppressor genes

Arnold J. Levine
From: Science & Medicine: Volume 2 Number 1: Page 28 (February 1995)

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Abstract: Mutations causing cancer alter the protein products of genes that regulate entry of the cell into the cell division cycle. The genes affected may be those that exert positive regulatory control, called proto-oncogenes if they are normal and oncogenes when mutated, or those that negatively regulate the cell cycle, which are the tumor supressor genes. Because there are safeguards built in to the system, more than one mutation must occur before a cancer will form. Proteins encoded by tumor viruses also inactivate the tumor suppressor gene products.

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