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Positional cloning

J. David Brook
From: Science & Medicine: Volume 1 Number 5: Page 48 (December 1994)

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Abstract: It is true of most human genetic diseases that neither the biochemical disorder nor the normal function of the affected gene is understood. In spite of that handicap, molecular geneticists have identified mutated genes associated with specified diseases. They do that by applying a series of procedures known as positional cloning. these techniques are also used in large-scale genome mapping projects (human and mouse), which will make genetic analysis an even more useful method.

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