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Helicobacter pylori binds to blood group antigens

Thomas Boren, Per Falk
From: Science & Medicine: Volume 1 Number 4: Page 28 (October 1994)

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Abstract: To survive and prosper in the highly acidic human stomach, H. pylori produces a potent urease that buffers its immediate environment. To colonize gastric epithelium, the microbe recognizes fucosylated blood group antigens known as H and Lewis b expressed on host cell surfaces. Finally, to avoid being flushed away in the rapid turnover of gastric mucosa, H. pylori has flagella that make it actively motile. These same characteristics together with secretion of a cytotoxin link H. pylori to chronic gastric inflammation and hint at possible ways to clarify its pathogenicity and to devise therapeutic strategies.

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