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Arterial plaque and thrombus formation

Neville Woolf, Michael J. Davies
From: Science & Medicine: Volume 1 Number 4: Page 38 (October 1994)

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Abstract: Several interdependent processes including the oxidation of low-density lipoprotein, formation of raised fatty streaks, and proliferation of smooth muscle cells are instrumental in the building of arterial fibrolipid plaques. Myriad chemical interactions hasten injury progression, and plaque fissuring also paves the way for acute thrombus development. The complexities of the process are not yet fully understood. However, because there are many steps in atherosclerosis there are also numerous possibilities for thereapeutic intervention.

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