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Regulation of myocardial adaptation

Larry Kedes
From: Science & Medicine: Volume 1 Number 3: Page 34 (August 1994)

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Abstract: Along with the sequencing of human genes and the cloning of their protein products, there is considerable progress being made in the characterization of how genes are regulated. Specific DNA sequences, mostly in the untranslated regions of the genome, are bound to proteins, some of which are found in all cells and some of which are cell-type-specific. These interactions are signals that influence gene expression. Regulation of genes responsible for producing the contractile protens of striated muscle has important clinical implications. Myocardial hypertrophy asociated with dynamic overload results from alterations in the regulatory mechanism.

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