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Estrogen actions in arteries, bone and brain

Philip M. Sarrel, Edward G. Lufkin, Merry Jo Oursler, David Keefe
From: Science & Medicine: Volume 1 Number 3: Page 44 (August 1994)

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Abstract: The clinical question whether post-menopausal hormone replacement therapy is advisable arises because the ovarian steroid hormones have widespread physiologic actions. How estrogens exert cardioprotective effects, the role of estrogens in bone turnover, and estrogen actions within the brain are being actively studied. Recent findings emphasize the importance of direct effects, particularly on cell membranes, that may also be involved in the response of the uterus, oviduct, and breast to circulating estrogens during the reproductive years.

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