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Influenza virus control of protein synthesis

Michele S. Garfinkel, Michael G. Katze
From: Science & Medicine: Volume 1 Number 3: Page 64 (August 1994)

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Abstract: Viruses must inhibit the expression of host cell gene products while viral mRNA is being translated instead. In order to do that, viruses must first down-regulate a protein kinase. Influenza virus type A has evolved especially clever ways to carry out these requirements for a successful infection. Accumulating knowledge of how infuenza viruses evade the cell's interferon response and alter gene expression provides a useful model for the study of these processes in uninfected cells.

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