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Autoimmunity

George S. Eisenbarth, Donald Bellgrau
From: Science & Medicine: Volume 1 Number 2: Page 38 (June 1994)

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Abstract: Most autoreactive T cells die during development, while those that remain do not recognize self antigens unless there is a triggering event. Autoimmune disease may occur when an individual inherits certain MHC class II alleles that present self antigens to activated T lymphocytes. Like other genetic disorders, autoimmune diseases frequently ocur in recognizable patterns or syndromes. For some of them the mechanisms of susceptability and protection are coming clear. The clinical problems are to identify susceptible individuals, predict the onset of disease, and prevent or cure autoimmune disorders. Progress at the molecular level suggest that solutions will be found.

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