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TH1 and TH2 subsets of CD4+ T lymphocytes

Sergio Romagnani
From: Science & Medicine: Volume 1 Number 2: Page 68 (June 1994)

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Abstract: Helper T cells bearing CD4 surface receptor molecules are active in both humoral and cellular immune responses. The two effector arms of the immune system act in coordination to control infection, and one arm or the other usually predominated, depending on the nature of the infectious microbe. The discovery that subsets of CD4+ TH cells are associated with different patterns of cytokine secretion has begun to expand the understanding that an immune response can be inappropriate rather than insufficient. The fact that the T cell subsets are counter-regulatory suggests therapeutic strategies and new approaches to vaccine development.

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