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Natriuretic peptides and receptors

David L. Armstrong, Richard E. White
From: Science & Medicine: Volume 1 Number 1: Page 34 (April 1994)

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Abstract: When retention of sodium and water stresses the mammalian cardiovascular system, atrial muscle cells release a polypeptide hormone to stimulate natriuresis and diuresis. Cell surface receptors for the atrial natriuretic peptide inhibit the release and action of other hormones on cells of the renal, endocrine, and cardiovascular systems by stimulating production of an intracellular messenger, cyclic guanosine monophosphate (cGMP). Recent studies of ion channel modulation by atrial natriuretic peptide on pituitary tumor cells suggest that many of its inhibitory actions can be explained by cGMP-dependent activation of a protein phosphatase.

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