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Radiolabeled antibodies

David M. Goldenberg
From: Science & Medicine: Volume 1 Number 1: Page 64 (April 1994)

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Abstract: The complexity of human cancer frustrates the perfection of cancer-specific therapy. Monoclonal antibodies labeled with radioactive agents have beeen shown to be useful in detecting and localizing tumors; therapeutic applications of such immunoconjugates are being introduced. Significant obstacles include variable (often low) tumor uptake, myelotoxicity that requires bone marrow transplantation or support, and the development of an immune response to repeated doses of foriegn immunoglobulins. Human or humanized antibody fragments employed as the basis for highly specific immunoconjugates are the most likely next step in the evolution of monoclonal antibody therapy.

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