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Doubly labeled water measures energy use

Steven B. Heymsfield, Dwight E. Matthews, Stanley Heshka
From: Science & Medicine: Volume 1 Number 1: Page 74 (April 1994)

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Abstract: Energy is liberated in cells when metabolic feuls are oxidized. Carbon dioxide, water, and heat are byproducts of the reactions. The energy content of the chemical bonds wihtin metabolic feuls is known, so the amount of energy released by the oxidation of a given amount of protein, glucose, or gat can be determined by measuring the consumption of oxygen and the production of CO2. Studying human nutrition and its disorders especially obesity, has been enhanced and simplifies by the availability of labeled oxygen. The administration of doubly labeled wter permits energy expenditure to be measured without altering a subject's patterns of normal activity.

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