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Insulin, C-peptide, and diabetic neuropathy

Anders A.F. Sima, Hideki Kamiya
From: Science & Medicine: Volume 9 Number 6: Page 308 (December 2003)

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Abstract: The conventionally held view is that the microvascular complications of diabetes are caused by hyperglycemia and therefore are the same in the two types of diabetes. Epidemiologic data suggest otherwise by demonstrating more severe and frequent complications in type 1 diabetes, a finding which is also borne out in rodent models. Recent data from several laboratories demonstrate that impaired insulin and C-peptide actions are likely to account for these differences. This likelihood has opened up new avenues for treating the microvascular complications in type 1 and possibly insulin-dependent type 2 diabetes. We propose that as with insulin therapy for hyperglycemic control, the synergistically active C-peptide needs to be replaced to prevent and treat the chronic complications.

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