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Multiple immune pathways participate in allograft rejection

Alain Le Moine
From: Science & Medicine: Volume 9 Number 6: Page 346 (December 2003)

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Abstract: Allograft rejection results from a complex interaction of the innate and acquired immune systems. Following the initial ischemia/reperfusion injury, innate immune responses predominate in the early phases of the alloreactive response. Donor and host dendritic cells migrate from the allograft to lymph nodes and present alloantigens for T-cell surveillance. Activated CD4+ T cells differentiate into Th1 and Th2 cells, which produce distinctive immune profiles. While cytotoxic T lymphoctyes and alloantibodies are the primary effectors of graft rejection, macrophages, neutrophils, eosinophils, and NK cells of the innate immune system also contribute. Because of the interaction of multiple pathways in allograft rejection, antigen-specific approaches will provide the best strategy to achieve transplant tolerance.

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