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p53 orchestrates multiple pathways for tumor suppression

Kelly Lynn Harms, Xinbin Chen
From: Science & Medicine: Volume 10 Number 1: Page 42 (February 2005)

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Abstract: Following cellular stress, p53 is activated to bind specific DNA sequences, inducing expression of target genes that mediate tumor suppression. By understanding the multiple signaling networks regulated by p53, it may be possible to identify novel genes and proteins amenable to therapies to overcome the p53 inactivation seen in many human tumors.

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