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HIV neuropathogenesis: persistent infection, persistent questions

Rajnish S. Dave, Roger J. Pomerantz
From: Science & Medicine: Volume 10 Number 2: Page 112 (April 2005)

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Abstract: HIV-1 appears to invade the CNS via brain microvascular endothelial cells, with the virus then entering macrophages and microglia. There, they proliferate and produce viral and cellular products that cause neuronal apoptosis. The CNS also might provide refuge from antiretroviral drugs, allowing more neurovirulent strains of HIV-1 to evolve under its protection.

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