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Vocal Fold Bioengineering

R.J. Clifton, T. Jiao, C. Bull, X. Jia
From: Science & Medicine: Volume 10 Number 3: Page 149 (June 2005)

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Abstract: An estimated 3 to 9% of the population is affected by some degree of vocal fold scarring. In June 2002, a new research initiative on vocal fold restoration was announced, with the goal being to reestablish normal vibratory characteristics to scarred vocal folds to help patients regain their normal voice. Since then, considerable research has been directed toward the design, synthesis, and characterization of biocompatible SLP substitutes at MIT and Brown University. Our strategies for voice restoration include three parallel approaches: the creation of injectable materials to improve pliability of damaged vocal folds; synthesis of a ¿designer material¿ to replace portions of the vocal folds; and use of tissue engineering methods to ¿grow¿ new vocal fold tissue.

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