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Anti-Adhesion Molecule Therapy for Inflammatory Bowel Disease

Gert Van Assche, Séverine Vermeire, Paul Rutgeerts
From: Science & Medicine: Volume 10 Number 3: Page 168 (June 2005)

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Abstract: Within the intestinal mucosa, adhesion molecules are involved in local lymphocyte stimulation and antigen presentation, as well as in the regulation of leukocyte influx. In inflammation, many adhesion molecules are upregulated, but a4-integrins likely hold a key position in directing leukocytes into the inflamed bowel wall. Compounds directed against leukocyte trafficking have been designed and are being developed as a novel class of drugs in the treatment of Crohn¿s disease and ulcerative colitis. In the near future, some of these novel biologic agents may prove valuable therapeutic tools in the management of refractory IBD.

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