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Chronic Inflammation, NF-kB, and Cancer

M. Bokulich
From: Science & Medicine: Volume 10 Number 3: Page 180 (June 2005)

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Abstract: The inflammatory microenvironment is characterized by the presence of activated macrophages and other immune cell types, which secrete a host of proinflammatory factors, such as cytokines, chemokines, and proteases. In chronic inflammation, this unabated immune response stimulates the proliferation of mutated cells, enhances their survival, and promotes angiogenesis, invasion, and metastasis. By regulating the expression of various factors that modulate the inflammatory processes, the transcription factor NF-kB appears to play a central role. Blocking NF-kB may offer a therapeutic option against cancer.

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