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A is for ... Notch


From: Science & Medicine: Volume 10 Number 3: Page 208 (June 2005)

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Abstract: The development of an organism from a single cell to a multicellular, three-dimensional structure of characteristic size and shape depends on the coordinated action of genes to direct the fate of individual cells. Neighboring cells also exchange signals to coordinate their respective behaviors and fates. Notch signaling is one of several signaling pathways, and possibly the most prevalent, used by metazoans to control cell fates through local cell¿cell interactions. Signals transmitted through Notch, in combination with other cellular factors, influence differentiation, proliferation, and apoptotic events at all stages of organogenesis and development.

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